The PTBA 211E ampoule breakpoint tester is designed and manufactured in compliance to the DIN EN ISO <9187-1/2:2010> standard. According to this standard the break point of ampoules has to be tested to control the quality during production of empty ampoules and prior to the filling process.

Advantages:
>> Breakpoint testing of empty ampoules in compliance with the DIN EN ISO <9187-1/2:2010>
>> Force standard setting: linear speed increase 10mm/min. (adjustable)
>> Automatic re-start facility to speed up the testing sequence
>> Entry of time and date
>> Enter a 12 digit batch number
>> Documentation of all results using a separate PCL5 or dot-matrix printer
>> Programmable print-out of force increase curve
>> Data transfer via RS-232 interface
>> Validation and calibration program for the measurement station
>> Dual point adjustment of the load cell for the hardness test station
>> Multiple point validation (calibration)

Dispersion Releaser – Release Apparatus for Nano- and Microformulations.
The Dispersion Releaser PT-DR is a dialysis-based apparatus for the release testing of nanomedicines, microformulations and semi-solid dosage forms within a standard dissolution tester. It is composed of a sample holder cell serving as the donor compartment for dispersed dosage forms. A dialysis membrane is disposed around this housing. This donor chamber is agitated by a paddle stirrer that is connected to the USP Apparatus 2.

Advantages:
>> Reproducible release through the additional stirring movement in the donor compartment
>> Increased throughput of the dialysis process
>> Mixing inside the donor and the acceptor compartment for an optimal homogeneous suspension

Dissolution Sampling Robot.
The DSR-M dissolution sampling robot is designed specifically for the sample transfer and sample processing from a six to twelve vessel dissolution bath. This unique versatile instrument allows samples to be collected over very short time intervals. The DSR-M can be equipped to collect, dilute or process samples for following UV-Visible or HPLC measurements. It can also be used for dissolution medium replenishment to conform to USP/EP volume loss rules.

Advantages:
>> Automates the taking of samples, the most labor intensive stage of a dissolution test
>> Automated sampling eliminates human errors as equal sampling times and standardized solvent transport offer high reproducibility
>> Flexible, modular design to allow auto media refill, dilution and transfer into sealed vials for six to twelve station dissolution baths
>> The CAT-MRM module eliminates the need for separate refilling tubing lines
>> Using the MFC-12 0.45 micron round filter can be exchanged easily and quickly between runs
>> Small footprint due to auto sampler design with integrated pump module
>> All moving parts are behind transparent enclosure to guarantee user safety

Precise Multi Syringe Pump.
The PT-SP multi-syringe pump is designed specifically for parallel sample withdrawal and dosage of media from a dissolution bath into open vials inside a fraction collector. It is equipped with up to 8 replaceable 10ml high precision glass syringes. Each syringe is connected to a 3-way pinch valve for media flow control. The drive of the syringes is carried out simultaneously by a stepper motor. All syringes are rigidly connected to the common sturdy drive bar.

Advantages:
>> Automates the removal of samples in connection with an integrated fraction collector the most labor intensive stage of a dissolution test
>> Automated sampling eliminates human errors as equal sampling times and standardized solvent transport offer high reproducibility
>> Syringe pump technology offers excellent precision and reproducibility for dissolution sampling and media replacement
>> Flexible, modular design allows to freely combine multiple pumps
>> Supports auto media refill for six to twelve station dissolution baths
>> All moving parts are behind a transparent enclosure to guarantee user safety while retaining visibility
>> DQ/QC, IQ and OQ documents included free of charge

Media Preparation and Degassing System.
Media degassing or “de-aeration”, pre-heating to a temperature of 37°C and absolutely precise gravimetric dispensing according to the recommendations and demanded for dissolution testing from the US FDA authorities are standard for the Pharma Test PT-DDS4 media preparation and degasing system. De-aeration is generally recommended to prevent the formation of bubbles on the dosage form surface, which may cause a variation in active dissolution rates, by virtue of surface obscuration.

Advantages:
>> De-aerates to approx. 35% of rest gas content (residual oxygen less than 5 ppm inside PT-DDS4 container)
>> Pre-heats your media to save time during start-up of dissolution tests
>> Fill-up program under pressure (connect directly to factory de-min. water supply)
>> Fill-up program under vacuum (prime from any external container)
>> Can be upgraded to de-aerate and dispense SPS foaming media
>> Can be used to directly dose into any vessel arrangement inside the dissolution bath
>> Special adapter to handle foaming media available (optional)
>> The instrument is movable and fits underneath most laboratory benches
>> Includes a balance (load cell) and all accessories for gravimetrical dosing
>> Good access to the media tank, easy to control the cleaning and test procedure
>> The only instrument which offers a software supported calibration program to validate and calibrate dosing accuracy using a certified 1 kg weight
>> Dosing performance test possible using built-in strain gauge
>> Correct dosing accuracy by entering density of media (changes because of temperature or solvent used)
>> Maximum of 2 liters waste when media change has to be done
>> Noise protected, max. noise level approx. 55dB
>> IQ/OQ documents included free of charge

Split Beam UV/VIS Spectrophotometer.
The T70 split-beam UV/VIS spectrophotometer offer excellent performance, high quality and are competitively priced. The T70 is well able to meet the stringent requirements required by analytical chemists. It features a wavelength range of 190 to 1100nm and is delivered with a built-in 8-cell changer as standard. It can therefore be used for both manual operation as well as for fully automated dissolution testing applications.

Advantages:
>> Excellent performance, high quality at a competitive price
>> Optimized for dissolution test applications
>> Data Printout to share data with other software. The results can be exported to Microsoft Word, Microsoft Excel, Text
>> Software Conforming to GLP
>> Log Record automatically records each operators usage, provides reliable database format to save the data log and administrator controlled access to log records and other useful tasks
>> Multi-User Management allows the administrator to create users and groups with different privileges. Access is controlled by user ID and password
>> Binary File Save Binary format to save measurement data. Binary format improves data security.
>> and saves disk space
>> Quality Control Monitor data according to the user’s setup. The system will take corrective
measures if the data is out of range
>> Printout Records of measurement results, personal settings for the report format and provides a print preview

21 CFR Part 11 compliance as well as compliance to the new requirements for Data Integrity
The WinDiss ARGUS Dissolution Software is a scientific dissolution data management software for instrument control, data acquisition, data management, processing and reporting – designed by users for users. WinDiss ARGUS Dissolution is compatible to almost all dissolution systems in the laboratory. Just one software needs to be trained and qualified. Whether you perform dissolution tests occasionally or several times each day WinDiss ARGUS Dissolution will make you more productive in running tests and analyzing results.

Advantages:
>> Instant recording of raw data
>> Standard database backup and recovery procedures
>> Long term persistence in XML
>> Detailed audit trail for electronic records
>> System log for tracking application events
>> Electronic signature support
>> Cryptographical record protection
>> Role specific access to program functions
>> IQ/OQ/PQ support with reminder function
>> Built in system suitability check
>> Failsafe technology for data recovery
>> Full Spectrometer OQ (as outlined in USP38)
>> Groupware Functionality (Enterprise Edition):
>> Method deployment via shared database
>> Centralized user account management
>> LDAP authentication (ActiveDirectory)
>> Prepared for LIMS connectivity
>> Review Data through your web browser

The PT-LT is used to test for the integrity of packed strips, blisters and small sachets containing tablets, granulates, liquids and so on. The instrument is used to test the quality of the packaging process and to check that the seals enclosing the product are perfectly intact. The PT-LT leak tester is designed to find the smallest holes and imperfections in blister packs and other semi-rigid product packaging. It is designed in compliance to the USP monograph <1136>.

Advantages:
>> Ensure the quality of your packaging process
>> Easy operation by programmed sequence
>> Fully automated microprocessor controlled equipment
>> Stainless steel housing to fit well into a production area
>> IQ/OQ documents included free of charge

The offline DFC systems include a fraction collector or an auto sampler which will collect the sampled dissolution media. The semi-automated DFC-120SP system is composed of a PTWS 120D or PTWS 120S staggered stirrer start dissolution bath with built-in individual vessel centering, full tubing installation in PTFE including in-situ sampling probes, a PT-SP8 syringe pump, and a PTFC-2/8 fraction collector. In this configuration the sampling probes are always immersed into the media (in-situ). This procedure is widely used.

Advantages:
>> The system automates the taking of samples, the most labor intensive stage of a dissolution test
>> Automated sampling eliminates human errors, as equal sampling times and standardized solvent transport offer high reproducibility
>> Excellent reproducibility of sampling volumes and times
>> Offers unattended operation after start of dissolution run
>> Pharma Test offers full system responsibility

The offline DFC systems include a fraction collector or an auto sampler which will collect the sampled dissolution media. The semi-automated DFC-820SP system is composed of a PTWS 820D staggered stirrer start dissolution bath with built-in individual vessel centering, full tubing installation in PTFE including either in-situ sampling probes or the EPE-820 auto sampling system, a PT-SP8 syringe pump, and a PTFC-2/8SP fraction collector. In this configuration the sampling probes are either always immersed into the media (in-situ) or removed after sampling (EPE-820 system). Both procedures are widely used.

Advantages:
>> The system automates the taking of samples, the most labor intensive stage of a dissolution test
>> Automated sampling eliminates human errors, as equal sampling times and standardized solvent transport offer high reproducibility
>> Excellent reproducibility of sampling volumes and times
>> Offers unattended operation after start of dissolution run
>> Pharma Test offers full system responsibility

The offline DFC systems include a fraction collector or an auto sampler which will collect the sampled dissolution media. The semi-automated DFC-620SP system is composed of a PTWS 620 staggered stirrer start dissolution bath with built-in individual vessel centering, full tubing installation in PTFE including either in-situ sampling probes or the EPE-620 auto sampling system, a PT-SP8 syringe pump, and a PTFC-2/8 fraction collector. In this configuration the sampling probes are either always immersed into the media (in-situ) or removed after sampling (EPE-620 system). Both procedures are widely used.

Advantages:
>> The system automates the taking of samples, the most labor intensive stage of a dissolution test
>> Automated sampling eliminates human errors, as equal sampling times and standardized solvent transport offer high reproducibility
>> Excellent reproducibility of sampling volumes and times
>> Offers unattended operation after start of dissolution run
>> Pharma Test offers full system responsibility

The offline DFC systems include a fraction collector or an auto sampler which will collect the sampled dissolution media. The semi-automated DFC-1220SP system is composed of a PTWS 1220 staggered stirrer start dissolution bath with built-in individual vessel centering, full tubing installation in PTFE including either in-situ sampling probes or the EPE-1220 auto sampling system, 2 PT-SP8 syringe pumps, and a PTFC-16 fraction collector. In this configuration the sampling probes are either always immersed into the media (in-situ) or removed after sampling (EPE-1220 system). Both procedures are widely used.

Advantages:
>> The system automates the taking of samples, the most labor intensive stage of a dissolution test
>> Automated sampling eliminates human errors, as equal sampling times and standardized solvent transport offer high reproducibility
>> Excellent reproducibility of sampling volumes and times
>> Offers unattended operation after start of dissolution run
>> Pharma Test offers full system responsibility

The online dissolution system ADS-L 1420 consists of the 14+2 vessel Pharma Test dissolution tester PTWS 1420, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.

Advantages:
>> Automation for optimization of laboratory processes
>> Offers unattended operation after start of dissolution run
>> Full spectral data in milliseconds
>> Multicomponent analysis with the TIDAS L 570 DAD UV/VIS spectrometer
>> Very short sampling time-intervals with the full spectral information
>> No media loss due to closed loop design
>> Pharma Test takes full system responsibility
>> Hardware IQ/OQ documents included free of charge

The online dissolution system ADS-L 120 consists of a Pharma Test dissolution tester PTWS 120, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant User friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.

Advantages:
>> Automation for optimization of laboratory processes
>> Offers unattended operation after start of dissolution run
>> Full spectral data in milliseconds
>> Multicomponent analysis with the TIDAS L 570 DAD UV/VIS spectrometer
>> Very short sampling time-intervals with the full spectral information
>> No media loss due to closed loop design
>> Pharma Test takes full system responsibility
>> Hardware IQ/OQ documents included free of charge

The online dissolution system ADS-L 820 consists of a Pharma Test dissolution tester PTWS 820D, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.

Advantages:
>> Automation for optimization of laboratory processes
>> Offers unattended operation after start of dissolution run
>> Full spectral data in milliseconds
>> Multicomponent analysis with the TIDAS L 570 DAD UV/VIS spectrometer
>> Very short sampling time-intervals with the full spectral information
>> No media loss due to closed loop design
>> Pharma Test takes full system responsibility
>> Hardware IQ/OQ documents included free of charge

The online dissolution system ADS-L 620 consists of a Pharma Test dissolution tester PTWS 620, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.

Advantages:
>> Automation for optimization of laboratory processes
>> Offers unattended operation after start of dissolution run
>> Full spectral data in milliseconds
>> Multicomponent analysis with the TIDAS L 570 DAD UV/VIS spectrometer
>> Very short sampling time-intervals with the full spectral information
>> No media loss due to closed loop design
>> Pharma Test takes full system responsibility
>> Hardware IQ/OQ documents included free of charge

The online dissolution system ADS-L 1220 consists of a Pharma Test dissolution tester PTWS 1220, the DAD UV/VIS spectrophotometer TIDAS® L and a multi-channel pump. The system is controlled by the 21 CFR Part 11 compliant user friendly WinDiss ARGUS dissolution software. All instruments are compliant to regulations from USP/JP/CP/EP/USFDA/ASTM and come with a 2 years warranty. One company is responsible for the support of all components.

Advantages:
>> Automation for optimization of laboratory processes
>> Offers unattended operation after start of dissolution run
>> Full spectral data in milliseconds
>> Multicomponent analysis with the TIDAS L 570 DAD UV/VIS spectrometer
>> Very short sampling time-intervals with the full spectral information
>> No media loss due to closed loop design
>> Pharma Test takes full system responsibility
>> Hardware IQ/OQ documents included free of charge

The PTG-S5 automated powder flow analyzer is used to measure the flow behavior of granules and powders in compliance with the EP <2.9.36>, EP <2.9.16>, USP <1174> Pharmacopoeia and ISO 4324 standards. This instrument determines the powder flow time, the powder cone angle of the collected powder mound, the weight, the density and the volume of the powder cone. Furthermore, the EP “flowability” result is calculated by measuring the flow time of 100g of sample through a specified pouring nozzle.

Advantages:
>> Reduce process costs
>> Improve product consistency from batch to batch
>> Keep tight control of component powders, especially if they are natural products
>> Compare sources of powdered products
>> Provides an easy method to achieve quality control on bulk incoming component products
>> Provides an easy method for the control of dry and wet mixing, tableting, granulating, and capsule filling
>> Predict powder transport through conveyors, air lifts and in silos
>> Predict powder suitability for capsule and bottle filling
>> Predict product settling during transport, so called classification
>> Predict powder influence on tablet hardness and solid dosage form stability
>> Predict powder influence on tablet disintegration and friability
>> Integrated clear view dust protection dust protection hood

The PTG-NIR automatic powder and granule analysis system combines the Pharma Test PTG-S5 powder flow testing instrument with an integrated J&M TIDAS L NIR diode array spectrometer. The system is controlled by the powerful TIDASDAQ3 software including a customized script for the PTG-NIR. The system is ideal to examine the flow characteristics of a powder or granule. This combination is ideal for simultaneous detection of chemical, physical and morphological information. This information is describing the flow behaviors of a powder or granule. Other forms of solids are possible to be tested too. All the results are presented in a single report generated by the included TIDASDAQ3 software.

Advantages:
>> Measure the flow behavior of powders and granules to reduce process costs and maintain quality and consistency of the final product
>> Gather chemical, physical and morphological information by using the integrated NIR spectrometer
>> Fast diode array NIR spectrometer provides immediate full spectra and contains no moving parts
>> Excellent S/N ratio to detect weak signals
>> IQ/OQ documents included free of charge

The PT-TD300 is used to test the tapped (or “tamped”) density and apparent density of powders, granules, pigments and similar products in compliance with the current USP <616> methods 1 and methods 2 as well as with EP <2.9.34>, DIN EN ISO 787-11, ASTM B527 and ASTM D7481.18. The instrument automatically calculates the tapped density, Hausner flowability ratio and Carr compressibility index after each test and documents the results via the integrated protocol printer.

Advantages:
>> Use a single instrument to test tapped density and apparent density according to both method 1 and method 2 from USP <616>
>> Automated detection of correct cylinder position according to selected method
>> Integrated protocol printer reduces bench space requirements
>> Detailed result report including calculation of Hausner flowability ratio and Carr compressibility index
>> Evaluation of the results according to Hausner and Carr compressibility indices
>> Determine the sample weight to automatically calculate apparent and tapped density
>> Programmable qualification interval timer reminds the user to perform instrument calibration
>> Dedicated calibration programs including reports for tap number, tap height, tap frequency, weight measurement and timer function
>> Copy methods between instruments by using a common USB flash drive
>> Export test reports as text files
>> IQ/OQ documents included free of charge

The PT-SV100 Scott Volumeter determines bulk density of powders according to the following standard Monographs: USP <616>, Method II bulk density and tapped density of powders, EP <2.9.34.1>, DIN ISO 3923-2 (metallic powders): determination of apparent density and optional ASTM B329 standard test method for apparent density of metal powders and compounds.

Advantages:
>> Easy to use
>> Solid design including vibration free baseplate
>> Integrated spirit gauge to check levelness of the instrument

The PTS 3E Suppository and Pessaries Disintegration Tester is designed and manufactured
in compliance to the EP monograph <2.9.2.1/2.9.2.2> and the German DAB Pharmacopoeia.
The PTS 3E is used for the manual measurement of suppositories and pessaries
disintegration times.

Advantages:
>> Removable bath, sample holder and test baskets for easy cleaning
>> Heating system is protected against any fat or grease intrusion
>> Tubular heater and powerful circulation pump system for even temperature distribution
>> IQ/OQ documents included free of charge

The SPT-6 Suppository Penetration Test assembly is used to determine the softening time of six samples at the same time. It is connected to a Pharma Test PTZ AUTO or PTZ-S tablet disintegration test instrument. The SPT-6 assembly can also be immersed into a suitable water bath. The SPT-6 is made in strict compliance with EP <2.9.22> Apparatus <A>. The assembly is placed into its own single position Plexiglas water bath. This way it is possible to use the SPT-6 in either a PTZ AUTO 1-4, PTZ AUTO 1EZ-4EZ or a PTZ-S tablet disintegration test instrument.

Advantages:
>> Fully automated detection of suppository softening time (with PTZ AUTO EZ only)
>> Round, clear-view waterbath for excellent visibility of all samples
>> Multi-purpose system: the disintegration testing instrument can still be used for regular tablet disintegration tests
>> IQ/OQ documents included free of charge

The PTSW-0 Suppository Dissolution Test Cell (Rotating Dialysis Cell) is placed into a standard USP type dissolution vessel which in turn is inserted into a standard tablet dissolution testing instrument to test the rate of dissolved active of suppositories and lipophilic carriers.

Advantages:
>> Can be used in a common dissolution bath having a suitable drive system (drive shaft design made to fit into Pharma Test dissolution bath only)
>> Easy to operate, set-up and remove for cleaning

The fully automated PTZ AUTO EZ instruments are available as single, double, triple and four station models. The instruments automatically detect the individual disintegration times of tablets and other solid dosage forms. Each automated disintegration basket can be operated independently and includes a temperature sensor. They are equipped in full compliance with the USP<701/2040> and EP<2.9.1/2.9.1.2> pharmacopoeia requirements.

Advantages:
>> Fully automated detection of individual disintegration end point times
>> Select from models with 1, 2, 3 or 4 stations to ideally meet your workload
>> Independent movement of all test stations
>> Automated lift to raise samples out of the medium at the end of a test
>> Integrated method management system
>> Excellent access to all vessels
>> DQ/QC, IQ and OQ documents included free of charge

The PTZ AUTO disintegration test instruments are available as single, double, triple and four station systems. Each disintegration basket can be operated independently. They are equipped in full compliance with the current USP <701/2040> and EP <2.9.1/2.9.2.1> Pharmacopoeia.

Advantages:
>> Select from models with 1, 2, 3 or 4 stations to ideally meet your workload
>> Independent movement of all test stations
>> Automated lift to raise samples out of the medium at the end of a test
>> Automated time log when disintegration is observed
>> Integrated method management system
>> Excellent access to all vessels
>> DQ/QC, IQ and OQ documents included free of charge

PTZ 100 is a single station tablet disintegration test instrument. PTZ 300 is the triple station version. Both instruments are manufactured in compliance to the USP <701/2040>, EP <2.9.1/2.9.2.1> and JP Pharmacopoeias. The instruments feature a method and user management system as well as an integrated report printer.

Advantages:
>> Graphical LCD screen showing actual and target settings
>> Integrated protocol printer reduces bench space requirements
>> Result report includes disintegration time, actual temperature and number of persisting samples
>> Password protected access through user management system
>> Programmable qualification interval timer reminds the user to perform instrument calibration
>> Dedicated calibration programs and reports
>> Copy methods between instruments by using a common USB flash drive
>> Export test reports as text files
>> Transmit test result to external systems such as LIMS
>> IQ/OQ documents included free of charge

The PTZ-S is a manual tablet disintegration testing instrument, manufactured according to the recent USP <701/2040>, EP <2.9.1/2.9.1.2>, JP and other pharmacopoeias. The PTZ-S is used for the manual testing of disintegration times of tablets, capsules and other solid dosage forms.

Advantages:
>> LED display informing of running time and firmware version
>> Totally silent operation of the stroke mechanism
>> Pre-programmable maximum disintegration time with Auto-Stop function
>> Vibration free movement, stroke height set to 55 mm at 30 strokes/min
>> Disintegration basket always stops at highest point
>> Built-in heating system includes overheating protection
>> Small footprint: approx. 42 x 26 x 42cm (width x depth x height)

The DIST-3 is a three-basket manual tablet disintegration testing instrument,
manufactured according to the recent USP <701/2040>, EP <2.9.1/2.9.1.2>, JP and other pharmacopoeias. The DIST-3 is used for the manual testing of disintegration times of tablets, capsules and other solid dosage forms.

Advantages:
>> LED display informing of running time and firmware version
>> Totally silent operation of the stroke mechanism
>> Pre-programmable maximum disintegration time with Auto-Stop function
>> Vibration free movement, stroke height set to 55 mm at 30 strokes/min
>> Disintegration basket always stops at highest point
>> Built-in heating system includes overheating protection
>> Small footprint: approx. 42 x 35 x 42cm (width x depth x height)

Orodispersible films (ODF) are a novel dosage form. Since 2012, they are monographed in European Pharmacopoeia (Ph.Eur. 7.4). Despite the fact that there are several film products available on the market, there has been no specific test method defined to characterize this dosage form.
The PT-ODF test basket for the PTZ AUTO EZ tablet disintegration testing instruments closes this gap by offering a simple and affordable device to reliably test the disintegration times of films. The PT-ODF basket can be used with any existing Pharma Test PTZ AUTO EZ instrument without any need for modification. It is attached directly to the PT-MKT electronic test baskets. A three position version for larger films is available as well. This requires a three position PT-MKT33 basket to use. The films are held in place by clamps.

Advantages:
>> A robust method to determine disintegration time of orodispersible films
>> Simple add-on system makes this a low cost upgrade from a standard PTZ AUTO EZ tablet disintegration testing instrument
>> PT-ODF basket add-on can be installed and removed easily and quickly

The PTWS 1420 is a 14+2-position, “dual drive” compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the BP, DAB and Japanese Pharmacopeia section <15>. The instrument features 14 testing positions and includes two additional standard size vessels for media refilling and reference standard media. PTWS 1420 features independent stirrer speed control for the left and right half of stirrers.

Advantages:
>> 14 stirred vessel in one instrument is ideal for Biowaiver applications and offline automated systems
>> Dual drive configuration with independent speed control for left and right side of instrument enables flexible use of the PTWS 1420
>> Replacement media is stored in two additional heated vessels eliminating influences from cold media refilling
>> Easy to use auto vessel centering system
>> Eco friendly double walled vacuum molded water bath for improved temperature insulation
>> Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
>> Wake up functionality to start heating at a pre-programmed time
>> Programmable infinity test
>> MonoShaft™ system to avoid re-adjustment of immersion depth after tool exchange
>> Staggered start feature for convenient manual sampling
>> Water diffuser for even temperature distribution
>> IQ/OQ documents included free of charge

The PTWS 120D is a 6 position, single drive compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the DAB and Japanese Pharmacopeia section <15>.

Advantages:
>> Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
>> Extraordinary safety features for pump and heating system, flow control, digital temperature control, thermo switch, thermo fuse
>> Ultra-fast heating system due to newly designed heat exchanger
>> Modular design to minimize bench space requirements
>> Individual vessel centering
>> Excellent access to all vessels
>> Eco-friendly double walled vacuum molded water bath

The PTWS 120S is a 6-position, multiple drive, compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section <2.9.3/4> as well as the BP, DAB and Japanese Pharmacopeia section <15>. Its design for manual operation and ease of use.

Advantages:
>> 6 stirring positions, individually electronically regulated high precision drive system for each one of the 6 stirrers.
>> Grouping of stirrers, like 2 groups of 3, or 3 groups of 2 running at the same speed
>> Modular design to minimize bench space requirements
>> 3-point individual vessel centering system
>> Borosilicate glass vessels including extra low evaporation vessel covers
>> Individual vessel batch code at the top of the vessel flange for easy identification
>> Excellent access to all vessels
>> Eco saving double walled vacuum molded water bath
>> Motorized Drive Head lifting mechanism including head position programming facility
>> Screen saver functionality and count-down timer offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
>> Wake up functionality to start heating at a pre-programmed time
>> Ultra-fast heating system due to newly designed heat exchanger, saves up to 1/3rd of the heating up time compared to most other models
>> MonoShaft™ system to avoid re-adjustment of immersion depth
>> Staggered stirrer start feature for convenient manual sampling
>> Water diffuser inside the vacuum moulded water bath for even temperature distribution and fast temperature equilibration
>> Spring loaded pump assembly to eliminate vibration transfer
>> Extraordinary safety features for pump and heating system, flow control, digital temperature control, thermo switch, thermo fuse
>> Auto stirrer stop when drive lift is moved
>> Excellent stirrer shaft verticality inside the vessels due to central position of lift columns, drive head assembly and rigid anodized aluminum framework
>> Easy removal of the water bath from of the frame work for cleaning and maintenance work
>> Energy saving double walled bath option, less heat transfer into the lab environment, less power consumption during instrument operation
>> DQ/QC, IQ and OQ documents included free of charge

The PTWS 820D is an 8-position, single drive compact tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section <2.9.3/4> as well as the DAB and Japanese Pharmacopeia section <15>.

Advantages:
>> Modular design to minimize bench space requirements
>> 3-point individual vessel centering system
>> Excellent access to all vessels
>> Eco saving double walled vacuum molded water bath
>> Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
>> Wake up functionality to start heating at a pre-programmed time
>> Ultra-fast heating system due to newly designed heat exchanger
>> MonoShaft™ system to avoid re-adjustment of immersion depth
>> Staggered stirrer start feature for convenient manual sampling
>> Water diffuser for even temperature distribution
>> Spring loaded pump assembly to eliminate vibration transfer
>> Extraordinary safety features for pump and heating system, flow control, digital temperature control, Thermo switch, Thermo fuse
>> Auto stirrer stop when instrument head is moved
>> Excellent stirrer shaft verticality inside the vessels due to central position of lift columns and drive head assembly
>> Easy removal of the water bath from of the frame work for cleaning and maintenance work
>> DQ/QC, IQ and OQ documents included free of charge

The Pharma Test media addition station PTWS 820-MA together with the PTWS 820D tablet dissolution testing instrument can be used to perform the automated media half change for delayed release dosage forms. The operation is performing according to the requirements from USP <711>, EP <2.9.3> and CP <931> for delayed release dosage forms (in CP, enteric coated dosage forms). The test will start with 750ml of 0.1N HCl. After 2 hours, 250ml of concentrated, pre-heated buffer solution will be dosed quickly into the dissolution vessels. The pH will change to 6.8 and the dosage form should then start to dissolve.

Advantages:
>> Very fast buffer adding which corresponds to a pump flowrate of 500ml/min
>> According to USP <711> and EP 2.9.3 the test must be “proceeded immediately” after the 2h in 0,1N HCl
>> Includes an additional heating system which will preheat the buffer in the USP Tolerance of 37 +/-0.5°C
>> No temperature change in the dissolution vessel
>> Unattended operation for the media change

The PTWS 620 is a 6 + 2 position, single drive tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the DAB/BP and Japanese Pharmacopeia section <15>. The USP monograph <1092/2.4.2> lists visual observation of the dissolution behavior as essential for identifying variables in the formulation or manufacturing process. The six vessels in the front row of PTWS 620 offer optimal visibility of the samples.

Advantages:
>> 6 front line vessels for easy access in manual operation and optimal visibility
>> Rigid aluminum water bath cover
>> Individual 3-point vessel centering
>> Excellent access to all vessels
>> Staggered start feature for convenient manual sampling
>> Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
>> Wake up functionality to start heating at a pre-programmed time
>> Programmable infinity test
>> MonoShaft™ system to avoid re-adjustment of immersion depth
>> Ultra-fast heating system with excellent temperature stability due to newly designed heat exchanger
>> Water diffuser for even temperature distribution
>> Vibration absorber to avoid vibration transfer into the USP/EP vessels
>> Spring loaded pump assembly to eliminate vibration transfer to the frame work
>> Extraordinary safety features for pump and heating system, flow control, digital temperature control, water level sensor, thermo switch, thermo fuse
>> DQ/QC, IQ and OQ documents included free of charge

The PTWS 1220 is a 6+6 position, single drive tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the DAB/BP and Japanese Pharmacopeia section <15>. The instrument features two additional vessels (approx. 250ml) for media refilling and reference standard media. The PTWS 1220 is the ideal choice for Biowaiver studies and dissolution method development.

Advantages:
>> Test 12 samples in one instrument with identical conditions for comparative studies (Biowaiver)
>> 6 front line and 6 back line vessels for easy access in manual operation
>> Rigid aluminum water bath cover
>> Individual 3-point vessel centering
>> Excellent access to all vessels
>> Staggered start feature for convenient manual sampling
>> Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
>> Wake up functionality to start heating at a pre-programmed time
>> Programmable infinity test
>> MonoShaft™ system to avoid re-adjustment of immersion depth
>> Ultra-fast heating system with excellent temperature stability due to newly designed heat exchanger
>> Water diffuser for even temperature distribution
>> Vibration absorber to avoid vibration transfer into the USP/EP vessels
>> Spring loaded pump assembly to eliminate vibration transfer to the frame work
>> Extraordinary safety features for pump and heating system, flow control, digital temperature control, water level sensor, thermo switch, thermo fuse
>> DQ/QC, IQ and OQ documents included free of charge

The PTWS D620 is a “Dual Drive” 6+6 position, single drive tablet dissolution testing instrument for solid dosage forms as described in USP chapter <711/724> and EP section<2.9.3/4> as well as the DAB/BP and Japanese Pharmacopeia section <15>. The instrument features two additional vessels (approx. 250ml) for media refilling and reference standard media. PTWS D620 features independent stirrer speed control for the front and back row of stirrers.

Advantages:
>> Individual speed control for front and back row of stirrers
>> 6 front line and 6 back line vessels for easy access in manual operation
>> Rigid aluminum water bath cover
>> Individual 3-point vessel centering
>> Excellent access to all vessels
>> Staggered start feature for convenient manual sampling
>> Screen saver functionality offers most important information at a glance (stirrer speed, bath temperature, time to next sampling interval, elapsed time, media temperature etc.)
>> Wake up functionality to start heating at a pre-programmed time
>> Programmable infinity test
>> MonoShaft™ system to avoid re-adjustment of immersion depth
>> Ultra-fast heating system with excellent temperature stability due to newly designed heat exchanger
>> Water diffuser for even temperature distribution
>> Vibration absorber to avoid vibration transfer into the USP/EP vessels
>> Spring loaded pump assembly to eliminate vibration transfer to the frame work
>> Extraordinary safety features for pump and heating system, flow control, digital temperature control, water level sensor, thermo switch, thermo fuse
>> DQ/QC, IQ and OQ documents included free of charge

The PT-DT70 is the low head flip back dissolution testing instrument from Pharma Test. It provides a spacen saving, low cost entry into dissolution testing. Whether for a new laboratory or to meet tough budget requirements, the PT-DT70 offers a lot of instrument for a comparatively modest cost. The ideal instrument for all USP <711/724> and EP <2.9.3/4> applications for which automated and manual operation is required.

Advantages:
>> 7 test stations = 1 additional unstirred vessel for blank or reference medium
>> 4 + 3 format for USA FDA friendly application
>> Pneumatic lift device which allows the drive head and testing tools to be raised out of the test vessels
>> Internal Buzzer, programmable sampling information
>> Housing made from stainless steel, top cover PP moulded
>> Full USP <711/724> / EP <2.9.3/4> Pharmacopoeia conformity
>> Mono-shaft Stirrers and Stirring Adapters fur USP/EP App. 1, 2 and 6 (Standard Supply Scope includes USP/EP App. 2 stainless steel Paddle Stirrer Adapters
>> Fully adjustable and fully regulated paddle speed selection from 25 to 250 rpm
>> Built in heater with microprocessor temperature control, over the range 25 to 45O Less than 0.3°C temperature deviation within the entire water bath
>> Measurable Vibration Displacement: < 0.003 mm (if placed onto a suitable bench)
>> LED display for target (user specified) and actual temperature
>> Bi-directional RS 232C interface for control of:
>> thermostat
>> temperature
>> motor start / stop
>> speed functions
>> connect PT-DL1 Data Logger
>> U-shaped Plexiglas (Perspex) water bath with cover for all 7 working positions. Auto centering system for all vessels. Heating of Dissolution Media in full compliance to the USP recommendation = no stirring while heating media to avoid air introduction!
>> Delivery scope includes 7 round bottom test vessels
>> Delivery scope includes a set of number stainless steel mono-shaft stirrers and paddle
inserts
>> Includes a locating gauge for setting stirrer depth and centering stirrer in vessel
>> Adjustable lock-nuts for exact positioning of stirrer shafts inside the test vessels
>> Built in calibration programs for speed and temperature

PTWS 4000 is the only tablet dissolution testing instrument available to support vessel sizes up to 4 liters for pool test applications of highly concentrated samples. PTWS 4000 contains six stirred glass vessels with a volume of approx. 4 liters each in a single row in the front side of the instrument. Furthermore, it offers two additional, unstirred 1 liter vessels to take a blank and/or a reference standard in a second row on the back side of the instrument. PTWS 4000 is fully compliant to the current USP <711/724> and EP <2.9.3/4> pharmacopeia.

Advantages:
>> The only tablet dissolution testing instrument supporting 4 liter vessels
>> Six vessels in front offer optimal view of the samples
>> Easy access to all vessels
>> Monoshaft™ system to avoid re-adjustment of immersion depth
>> Clear-view Plexiglass water bath for excellent visibility
>> TWS trafic light warning system monitors critical parameters
>> GMP compliant stainless steel housing
>> IQ/OQ documents included free of charge